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January 03, 2018

Synspira Announces $3 Million Development Award from Cystic Fibrosis Foundation

CAMBRIDGE, Mass. – January 3, 2018 – Synspira, a privately held company developing a new class of inhaled glycopolymer-based therapeutics for the treatment of pulmonary disease, today announced that it has received up to a $3 million award from the Cystic Fibrosis (CF) Foundation to advance clinical development of its lead candidate, SNSP113, for use in pulmonary complications of cystic fibrosis (CF).

SNSP113 is a novel glycopolymer representing a new class of molecules developed to treat infection, inflammation and congestion in the lungs associated with CF. Bacteria colonize and eventually form biofilms in the inflamed and mucus obstructed airways of persons with CF. Biofilms diminish the susceptibility of bacteria to antibiotics. SNSP113 breaks up bacterial biofilms and weakens bacteria, allowing for the potentiation of antibiotics. In addition, it diminishes mucus viscosity, reducing inflammation and promoting clearance of the lungs.

“This award will support the clinical development of SNSP113, which successfully completed a Phase 1a first-in-human trial to assess the safety and tolerability of single ascending doses in healthy individuals and will advance into stable CF patients in 2018,” said Shenda Baker, Ph.D., Chief Executive Officer of Synspira. “We have been working closely with the CF Foundation and are honored by their support and encouragement as we continue to develop therapies that are designed to improve quality of life for CF patients.”

About SNSP113

The company’s lead product, SNSP113, is a first-in-class inhaled glycochemistry-based therapeutic with a broad spectrum mechanism of action intended to target the underlying cascade of events that lead to progressive pulmonary disease or other life-threatening pulmonary conditions, such as nontuberculous Mycobacteria(NTM), Burkholderia cepacia complex (BCC), Pseudomonas aeruginosaor methicillin-resistant Staphylococcus aureus(MRSA). SNSP113 is designed to normalize mucin viscosity and improve mucus transport to increase airway clearance. SNSP113 disrupts the cohesion of bacterial biofilms and interacts with the cell walls of invading bacteria to increase their permeability, reduce their viability and potentiate the efficacy of antibiotics. These actions of SNSP113 lead to a reduction in the inflammatory cascade of neutrophils that can lead to pulmonary damage and fibrosis. Progressive pulmonary disease leads to overwhelming symptoms, impacts quality of life (QoL) and results in debilitating progressive lung decline. Synspira is expected to initiate SNSP113 Phase 2 trials in 2019.

About Synspira

Synspira Therapeutics is a clinical-stage biopharmaceutical company dedicated to significantly improving the lives of people with cystic fibrosis and other rare diseases, such as primary ciliary dyskinesia and bronchiectasis, where there is a high unmet treatment need. Synspira is a privately held company headquartered in Framingham, MA. The company’s lead product, SNSP113, is a first-in-class inhaled glycochemistry-based therapeutic with a broad spectrum mechanism of action designed to target the underlying cascade of events that lead to progressive pulmonary disease or other life-threatening pulmonary conditions. At Synspira we are inspired by the patients we serve and are driven to make a difference.

About Cystic Fibrosis

Cystic fibrosis (CF) is a progressive genetic disease that causes persistent lung infections and chronic inflammation of pulmonary tissue leading to permanent lung damage and ultimately resulting in respiratory failure. CF is characterized by the accumulation of thick, sticky mucus in the lungs and clogged airways which impede breathing. Bacteria are not easily cleared and create protective biofilms that are difficult for antibiotics to penetrate and often lead to the emergence of multi-drug resistant bacteria. More than 30,000 people in the United States, and a similar number in Europe, live with cystic fibrosis.