January 03, 2018
Synspira Announces $3 Million Development Award from Cystic Fibrosis Foundation
— Funding will support clinical development of SNSP113 —
CAMBRIDGE, Mass. – January 3, 2018 – Synspira, a privately held company developing a new class of inhaled glycopolymer-based therapeutics for the treatment of pulmonary disease, today announced that it has received up to a $3 million award from the Cystic Fibrosis (CF) Foundation to advance clinical development of its lead candidate, SNSP113, for use in pulmonary complications of cystic fibrosis (CF).
SNSP113 is a novel glycopolymer representing a new class of molecules developed to treat infection, inflammation and congestion in the lungs associated with CF. Bacteria colonize and eventually form biofilms in the inflamed and mucus obstructed airways of persons with CF. Biofilms diminish the susceptibility of bacteria to antibiotics. SNSP113 breaks up bacterial biofilms and weakens bacteria, allowing for the potentiation of antibiotics. In addition, it diminishes mucus viscosity, reducing inflammation and promoting clearance of the lungs.
“This award will support the clinical development of SNSP113, which successfully completed a Phase 1a first-in-human trial to assess the safety and tolerability of single ascending doses in healthy individuals and will advance into stable CF patients in 2018,” said Shenda Baker, Ph.D., Chief Executive Officer of Synspira. “We have been working closely with the CF Foundation and are honored by their support and encouragement as we continue to develop therapies that are designed to improve quality of life for CF patients.”
SNSP113 is a glycopolymer-based therapeutic being developed as an inhaled treatment to improve lung function in patients with cystic fibrosis. As a modified polysaccharide molecule, SNSP113 interacts with structural polymers in protective bacterial biofilms, breaking them apart, and with native glycoproteins in mucus, reducing mucus viscosity and adhesion. SNSP113 also interacts with the cell walls of invading bacteria increasing their permeability, thereby reducing their inherent viability and potentiating the efficacy of antibiotics. SNSP113 is designed to reduce infection and inflammation, the key drivers of pulmonary exacerbations and pulmonary decline in cystic fibrosis patients.
About Cystic Fibrosis
Cystic fibrosis (CF) is a progressive genetic disease that causes persistent lung infections and chronic inflammation of pulmonary tissue leading to permanent lung damage and ultimately resulting in respiratory failure. CF is characterized by the accumulation of thick, sticky mucus in the lungs and clogged airways which impede breathing. Bacteria are not easily cleared and create protective biofilms that are difficult for antibiotics to penetrate and often lead to the emergence of multi-drug resistant bacteria. More than 30,000 people in the United States, and a similar number in Europe, live with cystic fibrosis .
Synspira is developing a new class of inhaled glycopolymer-based therapeutics to reduce pulmonary inflammation and infection, key drivers of pulmonary diseases including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and pneumonia. Synspira has an exclusive license from Synedgen to the Glycomics Technology Platform for the development of inhaled therapeutics in pulmonary indications. Synspira is dedicated to developing drugs with new mechanisms of action to target and change the course of pulmonary diseases.
MacDougall Biomedical Communications